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Muscle atrophy and muscle contractures. Low stature (in men 160.2 ± 0.6, in women 146 ± 0.5). Short-fingered. III. All joints are deformed and get topamax . Their movements are severely limited. Low stature (in men 160.2 ± 0.6, in women 144 ± 0.5), short neck, bear's paw, genu valgum and genu varum, flat feet, lumbar hyperlordosis, duck gait. Women often have a narrow pelvis.

Moderate thickening of the proximal interphalangeal joints of the II, III, IV fingers, pain during exercise, slight limitation of movements in the wrist, elbow and ankle joints. II. Multiple lesions of the joints with their thickening, deformation, crunching and limitation of movement.

In addition to these changes, with Kashin-Bek disease of topiramate pills and III severity, neurodystrophic disorders can be observed: headaches, heart pain, poor appetite, wrinkled skin, dull nails and hair. Chronic atrophic rhinitis, pharyngitis, otitis media, bronchitis, pulmonary emphysema, gastritis, enterocolitis, vegetative-vascular dystonia, myocardial dystrophy, deformities of the teeth and jaws, neurological disorders (asthenoneurotic syndrome, encephalopathy) are often observed. Mental abilities decrease as the disease progresses.

It should be noted that if Kashin-Beck disease develops in adults, its clinical picture may be erased. Body temperature in patients is usually normal. In the blood and urine tests, no pathological abnormalities are detected. Sometimes hypochromic anemia, slight lymphocytosis, neutropenia are noted. The study of the mineral composition of the blood shows that the calcium content is increased, and phosphorus is reduced. In the urine, opposite changes are noted. Diagnosis of Kashin-Bek's disease.

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Kashin-Beck's disease is characterized by the following symptoms, which make it possible to make a diagnosis: pain and a loud crunch in the joints during movement, deformities and thickening of the joints, cessation of bone growth in length with a violation of topiramate, short fingers, short stature, joint contractures, lumbar hyperlordosis, on the x-ray the presence pathological deepening (niche) in the metaphyses of bones, mainly in the hands. Of great importance are anamnestic information about living in an endemic area.